Sympathetic signaling directs macrophage efferocytosis in thermogenic adipose tissue
Simon Meyer, Jennifer Witt, Imke Liebold, Tamara López-López, Laura Ehlen, Stephanie Leyk, Johanna Hiefner, Daniel Thomas Haas, Christian Schlein, Pablo José Sáez, Natalie Krahmer, Jöerg Heeren, Lorenz Adlung, Lidia Bosurgi, Anna Worthmann
The paper identifies norepinephrine as a trigger of macrophage efferocytosis in brown adipose tissue, linking sympathetic signaling to metabolic adaptation through β2-adrenergic and Axl/Mertk pathways.
bioRxiv · Oct 28, 2025 · PreprintImmunology