Author

David Chen

The Lundquist Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Immunology· 1 Molecular Biology· 1 Neuroscience· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:chicken / avian· 1

Frequent Co-Authors

Adrian Devitt-Lee· 1 shared Ameen Shaheen· 1 shared Celia R. Espinoza· 1 shared Ciaran McCarthy· 1 shared Clarissa TactoiD· 1 shared Courtney TindleiD· 1 shared Douglas R. Smith· 1 shared Eiji YOSHIHARA· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperPlant Biology

Adrian Devitt-Lee

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FXR and BET signaling orchestrate to protect β cells

Fritz Cayabyab, Jalan Tipirneni, David Chen, Jinhyuk Choi, Yu Hamba, Nhi Pham, Clarissa Tacto, Jie Wu, Liu Wang, Yeva Mirzakhanyan, Paul David Gershon, Harvey Perez, Naoki Harada, Kiyoka Kim, Ameen Shaheen, , Eiji YOSHIHARA

This study identifies FXR and BET signaling cooperation in protecting β cells from diabetes-related dysfunction through protein interaction and functional synergy.

bioRxiv · Apr 14, 2026 · PreprintMolecular Biology

A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control

Mahitha Shree Anandachar, David Chen, Kennith Carpio-Perkins, Gajanan Dattatray Katkar, Suchismita Roy, Celia R. Espinoza, Madhubanti Mullick, Saptarshi Sinha, Michelle Nakayama, Jasmin Salem, Megan L. Estanol, Rishav Bhattacharjee, Kameron M. Zablan, S. Hsu, Sinclair Williams, , Pradipta Ghosh

This paper identifies a host-encoded toggle switch involving NOD2 and GIV that controls cAMP levels in macrophages, converting tolerant cells into microbicidal machines to restore microbial clearance and gut barrier integrity.

bioRxiv · Mar 31, 2026 · PreprintImmunology

Brain-engrafted macrophages provide protection against therapeutic irradiation and secondary concussive injury

Xi Feng, Elma S. Frias, Maria S. Paladini, David Chen, Zoe Boosalis, McKenna Becker, Sonali Gupta, Sharon Liu, Nalin Gupta, Susanna Rosi

This study shows that brain-engrafted macrophages protect against radiation-induced cognitive deficits and concussive injury by replacing microglia and altering their functional properties.

bioRxiv · Jul 12, 2021 · PreprintNeuroscience

Endogenous synthesis of pyrethrins by cannabis

Adrian Devitt-Lee, Douglas R. Smith, David Chen, Kevin McKernan, Simone Groves, Ciaran McCarthy

The paper shows cannabis can produce pyrethrins endogenously, with genetic evidence and low-level pyrethin I detection in cannabis flowers.

bioRxiv · Jul 28, 2017 · PreprintPlant Biology