Author

David Chetrit

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Craig R. RoyiD· 3 shared Erdem KaratekiniD· 2 shared Amit MeiriD· 1 shared Ane LandajuelaiD· 1 shared Boris MačekiD· 1 shared Carmen BuchrieseriD· 1 shared Derek K. ToomreiD· 1 shared Donghyun Park· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

Craig R. RoyORCID

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Author profile →

4 papers

Recent·Most cited

Type IV Secretion System Drives Lipid Mixing

David Chetrit, Craig R. Roy, Erdem Karatekin

This study shows that Type IV Secretion Systems (T4SSs) prime for substrate delivery through contact-induced lipid mixing, not requiring ATP or full complex assembly, and this mechanism applies to both Dot/Icm and RK2 T4SSs.

bioRxiv · Jan 15, 2026 · PreprintMicrobiology

In-situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation

Jian Yue, Samira Heydari, Donghyun Park, David Chetrit, Shoichi Tachiyama, Wangbiao Guo, Jack M. Botting, Shenping Wu, Craig R. Roy, Jun Liu

This study uses cryo-electron microscopy to reveal the structure of the Dot/Icm T4SS in Legionella pneumophila, identifying the DotA-IcmX complex as the gatekeeper for effector translocation.

Proceedings of the National Academy of Sciences · Sep 23, 2025Peer-reviewedMolecular Biology

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1

Maria Tsemperouli, Sudheer Kumar Cheppali, Félix E. Rivera-Molina, David Chetrit, Ane Landajuela, Derek K. Toomre, Erdem Karatekin

This study shows that mutations in Syt1's C2 domains impair DCV docking but increase fusion pore size and serotonin release speed.

Biophysical Journal · Dec 24, 2024Peer-reviewedBiophysics

The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors

Silke Malmsheimer, Iwan Grin, Erwin Bohn, Mirita Franz‐Wachtel, Boris Maček, Tobias Sahr, Fabian Smollich, David Chetrit, Amit Meir, Craig R. Roy, Carmen Buchrieser, Samuel Wagner

This study investigates the secretion mechanism of transmembrane effector proteins by Legionella T4bSS, revealing a two-step process involving an inner membrane intermediate.

PLoS Pathogens · Nov 15, 2024Peer-reviewedMicrobiology