The Histone Methyltransferase KMT2D promotes Natural Killer cell effector molecule release
Katelynn R. Kazane, Jeong Hyun Ji, Georgia R. Lill, Sebastian Zolog, Christian G. Bustillos, David Hsieh, Evelyn Hernandez-Almonte, Luis Alberto Pedroza, Maureen A. Su, Jordan Scott Orange, Timothy Edward O’Sullivan
This study shows that KMT2D promotes effector molecule release in NK cells by regulating H3K4me1 and RAB3D levels, affecting cytotoxicity and cytokine production.
bioRxiv · Sep 22, 2026 · PreprintImmunology