Author

David MacKenzie MacLeod

MRC Centre for Regenerative Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dónal O’CarrolliD· 2 shared Ahmet ŞalvarcıiD· 1 shared Aleksandra RosińskaiD· 1 shared Ansgar ZochiD· 1 shared Arockia Jeyaprakash ArulanandamiD· 1 shared Atlanta G. CookiD· 1 shared Birgit StallmeyeriD· 1 shared Christos SpanosiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Dónal O’CarrollORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The structure of the apo-PIWI HSP90 complex

Peter Donlon, Paula Sotelo‐Parrilla, David MacKenzie MacLeod, Aleksandra Rosińska, Tamoghna Chowdhury, Katherine Isabella Leith, Ansgar Zoch, Christos Spanos, Atlanta G. Cook, Arockia Jeyaprakash Arulanandam, Dónal O’Carroll

The paper determines the structure of the apo-PIWIL4-HSP90 complex and shows it adopts an open conformation distinct from piRNA-bound PIWI.

bioRxiv · Jul 6, 2026 · PreprintMolecular Biology

HSP90AA1 variants may contribute to autosomal dominant human male infertility

Margot Julia Wyrwoll, David MacKenzie MacLeod, Ahmet Şalvarcı, Sabine Kliesch, Özlem Okutman, Stéphane Viville, Birgit Stallmeyer, Frank Tüttelmann, Dónal O’Carroll

This study investigates whether HSP90AA1 variants cause autosomal dominant male infertility in humans and finds that while some variants are associated with infertility, their pathogenicity remains uncertain.

medRxiv · Feb 22, 2026 · PreprintGenetic & Genomic Medicine