Author
Ludwig-Maximilians-Universität MünchenORCID 0000-0002-1889-8635Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Peter Donlon, Paula Sotelo‐Parrilla, David MacKenzie MacLeod, Aleksandra Rosińska, Tamoghna Chowdhury, Katherine Isabella Leith, Ansgar Zoch, Christos Spanos, Atlanta G. Cook, Arockia Jeyaprakash Arulanandam, Dónal O’Carroll
The paper determines the structure of the apo-PIWIL4-HSP90 complex and shows it adopts an open conformation distinct from piRNA-bound PIWI.
bioRxiv · Jul 6, 2026 · PreprintMolecular Biology
Anjitha Gireesh, Maria Alba Abad, Ryu‐Suke Nozawa, Paula Sotelo‐Parrilla, Léa C Dury, Mariia Likhodeeva, Christos Spanos, Cristina CARDENAL PERALTA, Juri Rappsilber, Karl‐Peter Hopfner, Marcus D. Wilson, Willem Vanderlinden, Toru Hirota, Arockia Jeyaprakash Arulanandam
This study reveals how the chromosomal passenger complex (CPC) interacts with nucleosomes to protect centromeric chromatin, showing its non-catalytic role in maintaining chromatin stability.
bioRxiv · May 15, 2025 · PreprintBiochemistry
Kumiko Samejima, Johan Harmen Gibcus, Sameer Abraham, Fernanda Cisneros-Soberanis, Itaru Samejima, Alison J. Beckett, Nina Pucekova, Maria Alba Abad, Christos Spanos, Bethan Medina‐Pritchard, James R. Paulson, Linfeng Xie, Arockia Jeyaprakash Arulanandam, Ian A. Prior, Leonid A. Mirny, , William C. Earnshaw
In DT40 cells, condensins displace extrusive cohesin, bypass cohesive cohesin and stall against each other while extruding ~1-3 kb/sec, yielding irregular helical chromatids of consecutive loops.
Science · Apr 10, 2025Peer-reviewedMolecular Biology✦ In-depth digest