Eradication of ENO1-deleted Glioblastoma through Collateral Lethality
Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Sunada Khadka, Victoria C. Yan, Dimitra K. Georgiou, Yuting Sun, Rafal Zielinski, Theresa Tran, Susana Castro Pando, Xiaobo Wang, David Maxwell, Zhenghong Peng, Federica Pisaneschi, , Florian L. Muller
The paper demonstrates that POMHEX, a modified phosphonate antibiotic, effectively eradicates ENO1-deleted glioblastoma in vivo without causing hemolytic anemia.
bioRxiv · May 25, 2018 · PreprintCancer Biology