Author

David Zapletal

Masaryk University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Diego F. JosephiD· 2 shared Josef PasulkaiD· 2 shared Karel KubíčekiD· 2 shared Petr SvobodaiD· 2 shared Radek Malı́kiD· 2 shared Richard ŠtefliD· 2 shared Valéria BuccheriiD· 2 shared Christian MuchiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Diego F. JosephORCID

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2 papers

Recent·Most cited

A negatively charged unstructured loop autoinhibits mammalian Dicer and supports fidelity of miRNA biogenesis.

Diego F. Joseph, N. V. Noskova, Radek Malı́k, David Zapletal, Josef Pasulka, Valéria Buccheri, David Buchta, Ján Petrovský, Karel Kubíček, Petr Svoboda, Richard Štefl

The paper shows that a negatively charged intrinsically disordered region (IDR) in Dicer autoinhibits the enzyme and ensures fidelity of miRNA biogenesis.

bioRxiv · Feb 20, 2026 · PreprintMolecular Biology

Molecular basis of indispensable accuracy of mammalian miRNA biogenesis

David Zapletal, Eliška Táborská, Josef Pasulka, Radek Malı́k, Karel Kubíček, Martina Zanova, Christian Much, Marek Šebesta, Valéria Buccheri, Filip Horvat, Irena Jenickova, Michaela Procházková, Jan Procházka, Matyáš Pinkas, Jiří Nováček, , Petr Svoboda

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

bioRxiv · Apr 13, 2022 · PreprintMolecular Biology