Richard Štefl

The paper shows that a negatively charged intrinsically disordered region (IDR) in Dicer autoinhibits the enzyme and ensures fidelity of miRNA biogenesis.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.

The paper shows that the SOSS1 complex and RNA polymerase II form phase-separated compartments at double-strand breaks to facilitate DNA repair.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

The paper identifies a CTD-mimic motif in Sen1 that interacts with Nrd1's CTD-interacting domain to facilitate ncRNA termination in yeast.