Author

Deeksha Lahori

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jonathan SchugiD· 4 shared Klaus H. KaestneriD· 4 shared Ali NajiiD· 3 shared Hélène C. DescampsiD· 3 shared Chengyang LiuiD· 2 shared Elisabetta ManduchiiD· 2 shared Hilana El‐MekkoussiiD· 2 shared Tong DaiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenomics

Jonathan SchugORCID

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4 papers

Recent·Most cited

Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes

Elisabetta Manduchi, Hélène C. Descamps, Jinping Liu, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El‐Mekkoussi, Michelle Lee, Eseye Feleke, Diana Bernstein, Chengyang Liu, Ali Naji, Benjamin Glaser, Klaus H. Kaestner, Dana Avrahami

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

bioRxiv · Jul 2, 2025 · PreprintGenomics

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas

Michelle Y. Y. Lee, Omar Guessoum, Hilana El‐Mekkoussi, Mitchell Conery, Elisabetta Manduchi, Jonathan Schug, Hélène C. Descamps, Deeksha Lahori, Tong Da, Chengyang Liu, Ali Naji, Benjamin F. Voight, Mingyao Li, Klaus H. Kaestner

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

bioRxiv · Feb 14, 2025 · PreprintSystems Biology

Villification of the intestinal epithelium is driven by Foxl1

Guoli Zhu, Deeksha Lahori, Jonathan Schug, Klaus H. Kaestner

This study identifies Foxl1 as a key driver of intestinal villification by regulating BMP, PDGFR, and planar cell polarity genes in telocyte progenitors.

bioRxiv · Feb 27, 2024 · PreprintDevelopmental Biology

Modeling Type 1 Diabetes progression from single-cell transcriptomic measurements in human islets

Abhijeet R. Patil, Jonathan Schug, Chengyang Liu, Deeksha Lahori, Hélène C. Descamps, Ali Naji, Klaus H. Kaestner, Robert B. Faryabi, Golnaz Vahedi

This study uses single-cell transcriptomics and machine learning to predict T1D development in autoantibody-positive donors and identifies shared gene signatures across cell types.

bioRxiv · Jul 19, 2023 · PreprintGenomics