Hélène C. Descamps

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

This study uses single-cell transcriptomics and machine learning to predict T1D development in autoantibody-positive donors and identifies shared gene signatures across cell types.