Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes
Elisabetta Manduchi, Hélène C. Descamps, Jinping Liu, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El‐Mekkoussi, Michelle Lee, Eseye Feleke, Diana Bernstein, Chengyang Liu, Ali Naji, Benjamin Glaser, Klaus H. Kaestner, Dana Avrahami
The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.
bioRxiv · Jul 2, 2025 · PreprintGenomics