Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart
Paul Kießling, Mehdi Joodaki, Daryna Pikulska, Emilia Scheidereit, Giulia Cesaro, Mayra Ruiz, Damin Kühn, Kai Peng, Osman Goni, Sebastian Foecking, Samaneh Samiei, Xian Liao, Kai Li, Zihao Feng, Delin Wang, , Christoph Kuppe
This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.
bioRxiv · Feb 14, 2026 · PreprintGenomics