Induction of hysteretic chromatin states by CRISPRa reveals locus-specific encoding of transcriptional memory
Guy C. Bedford, Sangrok Han, Derek L. Yang, Devika Dua, Hakeem Shitta-Bey, Michael A. Beauregard, Andrew R. DiNardo, Isaac B. Hilton, Michael R. Diehl
The paper uses CRISPRa to show that transcriptional memory can be induced in MSCs through locus-specific activation, linked to H3K27me3 loss and increased transcription factor reacquisition.
bioRxiv · Sep 30, 2026 · PreprintMolecular Biology