Molecular BiologybioRxivPreprint
Induction of hysteretic chromatin states by CRISPRa reveals locus-specific encoding of transcriptional memory
Guy C. Bedford, Sangrok Han, Derek L. Yang…·Michael R. Diehl
The paper uses CRISPRa to show that transcriptional memory can be induced in MSCs through locus-specific activation, linked to H3K27me3 loss and increased transcription factor reacquisition.