CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models
Timothy Hammond, Gregory S. Wirak, Sean K. Ryan…·Dimitry Ofengeim
This study shows CD40L and IFN-γ induce inflammation and neurodegeneration in human stem cell-derived microglia, suggesting CD40L blockade as a potential MS therapy.