Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein
Lisha Arora, Dipankar Bhowmik, Snehasis Sarkar, Anusha Sarbahi, Sandeep K. Rai, Samrat Mukhopadhyay
This study shows that Ydj1, an Hsp40, prevents amyloid formation of the Y145Stop prion protein variant through heterotypic phase separation.
Journal of Molecular Biology · Jan 16, 2025Peer-reviewedBiophysics