Snehasis Sarkar

An autoinhibitory regulatory switch governs heterotypic phase separation and liquid-to-solid phase transition of TDP-43 and tau into cytotoxic amyloids

The paper investigates how TDP-43 and tau undergo heterotypic phase separation and transition into cytotoxic amyloids, revealing an autoinhibitory switch that regulates this process.

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein

This study shows that Ydj1, an Hsp40, prevents amyloid formation of the Y145Stop prion protein variant through heterotypic phase separation.