Author

Dirk Elewaut

Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics, Ghent University, Gent, Belgium;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alba Sanz-Sanjuan· 1 shared Alexandra Circiumaru· 1 shared Álvaro Furones Cuadrado· 1 shared Arnaud Huard· 1 shared Assunta Caruso· 1 shared Axel FinckhiD· 1 shared Celine Lamacchia· 1 shared Cem GabayiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alba Sanz-Sanjuan

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2 papers

Recent·Most cited

IL-23 licenses the transition from preclinical autoimmunity to inflammatory arthritis through IL-17A-dependent mechanisms

Matthias Jarlborg, Alexandra Circiumaru, Celine Lamacchia, Laurie Vaillant, Erik Rakotoarijaonina, Koen Venken, Dirk Elewaut, Emiliana Rodriguez, Assunta Caruso, Arnaud Huard, Luca Santuari, Nylsa Chammartin, Delphine S Courvoisier, Massimo Andreatta, Santiago J Carmona, , Cem Gabay

This study shows IL-23 promotes the transition from preclinical autoimmunity to arthritis by enhancing IL-17A and IFN-gamma production, and identifies IL-23 pathway changes in at-risk individuals.

bioRxiv · Nov 4, 2026 · PreprintImmunology

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

Danielle M. Clancy, Alba Sanz-Sanjuan, Elisabeth Gilis, Peter Tougaard, Imke Velghe, Yana Van Droogenbroeck, Jan Félix, Yehudi Bloch, Álvaro Furones Cuadrado, Romain Merceron, Stephan Schenck, Peter Vandenabeele, Janine D. Brunner, Tom Taghon, Dirk Elewaut, Savvas N. Savvides

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

bioRxiv · Feb 16, 2025 · PreprintImmunology