Modelling the human IL6RA Asp358Ala variant in mice: effects on atherosclerosis and abdominal aortic aneurysm
Minoru Takaoka, Rahul Sharma, Fabien Lareyre, Marc Clément, James Harrison, Leanne Masters, Yuning Lu, Dirk Paul, Ziad Mallat
This paper shows that introducing the IL6RA Glu357Ala substitution in mice reduces atherosclerosis and AAA, similar to the human IL6RA Asp358Ala variant's protective effect.
bioRxiv · Oct 21, 2026 · PreprintPathology