SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease
Akshay Sharma, Suman Saurav, Preity Sharma, Deepika Pandhi, Anushka Agrawal, Nutan Sharma, Gyan Ranjan, Divya Bhalla, Vamsi Krishna Yenamandra, Jyoti Tanwar, Rajender K. Motiani
This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.
Cell Calcium · Sep 24, 2026Peer-reviewedCell Biology