Author

Akshay Sharma

Regional Centre for BiotechnologyORCID 0009-0004-9251-6377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Rajender K. MotianiiD· 4 shared Suman Saurav· 3 shared Gyan RanjaniD· 2 shared Amit Kumar BhattiD· 1 shared Ananda Kishore MukherjeeiD· 1 shared Anindya DuttaiD· 1 shared Ankita SinghiD· 1 shared Antara SenguptaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCell Biology

Rajender K. MotianiORCID

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4 papers

Recent·Most cited

Cell BiologyCell CalciumPeer-reviewedSep 24, 2026

SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s Disease

Akshay Sharma, Suman Saurav, Preity Sharma…·Rajender K. Motiani

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

DOI 10.1016/j.ceca.2026.103199

humanexperimental assay

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Cell BiologyThe EMBO JournalPeer-reviewedSep 29, 2025

NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase

Sharon Raju, Akshay Sharma, Sakshi Dahiya…·Rajender K. Motiani

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

8 citations

humanproteomics

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Cancer BiologyeLifePeer-reviewedMar 18, 2025

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

Antara Sengupta, Soujanya Vinayagamurthy, Dristhi Soni…·Shantanu Chowdhury

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

4 citations

humanChIP-seq

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BiochemistryCell CalciumPeer-reviewedAug 12, 2024

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

Oishika Chatterjee, Jagannath Jana, Suman Panda…·Subhrangsu Chatterjee

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

2 citations

humanChIP-seq

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