Rajender K. Motiani

This study identifies TRPM2 as a suppressor of pigmentation through type-I interferon signaling in melanocytes, revealing a novel signaling axis linking immune surveillance to pigmentation homeostasis.

This study identifies SERCA2b as a negative regulator of pigmentation through ER stress and mitochondrial calcium uptake, linking its loss to hyperpigmentation in Darier’s Disease.

This study shows alcohol exposure causes shared calcium signaling changes in zebrafish hepatocytes and pancreatic acinar cells, with tissue-specific molecular mechanisms involved.

This paper shows NFAT2 regulates Orai3 expression differently in non-metastatic and metastatic cancer cells through transcriptional activation and MARCH8-mediated degradation, linked to MARCH8 promoter methylation.

This paper identifies Orai3 as a driver of gemcitabine resistance in pancreatic cancer through the Orai3-NFATc1-SLIT3 signaling pathway, showing its role in cell proliferation, apoptosis, and metastasis.

This paper identifies IP3R2 as a negative regulator of melanophagy, showing it controls melanosome degradation through Ca2+ signaling and lysosomal pathways.

This study identifies TAAL, a lncRNA that modulates Tie1 signaling and vascular function in diabetic retinopathy, showing its role in endothelial cell behavior and potential therapeutic relevance.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

This study identifies H2a.z.2 as a histone variant that biases neural crest cells toward the melanocyte lineage by enhancing Mitf promoter activation.