Author

Dominic Samaroo

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Frederic D. DariosiD· 2 shared Margaux Cauhapé· 2 shared Alexandra DürriD· 1 shared Alexia MenuetiD· 1 shared Belinda Simone CowlingiD· 1 shared Benoît ColschiD· 1 shared Filippo Maria SantorelliiD· 1 shared Giovanni StévaniniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Frederic D. DariosORCID

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2 papers

Recent·Most cited

SPG11 models reveal lysosomal calcium as a regulator of neural progenitor proliferation

Dominic Samaroo, Margaux Cauhapé, Léa Bernachot, Frederic D. Darios

This study shows that SPG11 mutations cause lysosomal calcium accumulation, reducing neural progenitor proliferation and affecting mTOR signaling in cortical development.

bioRxiv · Jul 21, 2025 · PreprintCell Biology

Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice

Manon Fortier, Margaux Cauhapé, Suzie Buono, Julien Becker, Alexia Menuet, Julien Branchu, Ivana Ricca, Serena Mero, Karim Dorgham, Khalid Hamid El Hachimi, Kostantin Dobrenis, Benoît Colsch, Dominic Samaroo, Morgan Devaux, Alexandra Dürr, , Frederic D. Darios

This study shows that reducing ganglioside synthesis delays motor and cognitive symptoms in Spg11 knockout mice and reduces axonal spheroids.

bioRxiv · Jan 29, 2024 · PreprintNeuroscience