Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice
Manon Fortier, Margaux Cauhapé, Suzie Buono, Julien Becker, Alexia Menuet, Julien Branchu, Ivana Ricca, Serena Mero, Karim Dorgham, Khalid Hamid El Hachimi, Kostantin Dobrenis, Benoît Colsch, Dominic Samaroo, Morgan Devaux, Alexandra Dürr, , Frederic D. Darios
This study shows that reducing ganglioside synthesis delays motor and cognitive symptoms in Spg11 knockout mice and reduces axonal spheroids.
bioRxiv · Jan 29, 2024 · PreprintNeuroscience