The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis
Isabelle Coppens, Shahbaz Khan, Yevel Flores-García, Jiro Sakai, Mustafa Akkoyunlu, Julia D. Romano, Karen Ehrenman, Viviana Pszenny, Michael E. Grigg, Krishna Manuguri, Yue Zhao, Duanpei Wang, Fidel P. Zavala
This paper develops a live-attenuated Toxoplasma vaccine by knocking out DGAT1, showing it provides long-term protection against both acute and chronic toxoplasmosis.
bioRxiv · Aug 19, 2026 · PreprintMicrobiology