Duc Duong

The Alzheimer's disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

PSEN1 mutant marmoset fibroblasts mimic multi-omic signatures of Alzheimer's disease

This study shows that PSEN1 mutant marmoset fibroblasts exhibit multi-omic signatures similar to Alzheimer's disease in humans, highlighting sex-specific differences and disease-relevant pathways.

Neurodegeneration risk variants promote lysosomal TMEM106B fibrilaccumulation

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

Convergent effects of neurodevelopmental disorder-associated variants at mitochondria

The paper investigates how neurodevelopmental disorder-associated variants affect mitochondrial proteins and finds convergent effects on mitochondrial translation in two high-risk CNVs.

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathy

The paper treats early-stage tau transgenic mice with a multi-target kinase inhibitor, showing cognitive improvement and proteomic shifts similar to Alzheimer's disease in humans.