Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathy
Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad A. Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle C. Bell, Sara María Galvis Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David K. Powell, , Jose Francisco Abisambra
The paper treats early-stage tau transgenic mice with a multi-target kinase inhibitor, showing cognitive improvement and proteomic shifts similar to Alzheimer's disease in humans.
bioRxiv · Jul 31, 2020 · PreprintNeuroscience