Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair
Yang Jiang, Moritz Jakob Przybilla, Linda V. Bakker, Foster C. Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E. E. Verkennis, Jamie T. Barnett, Adrian Baez‐Ortega, Federico Abascal, Peter W. Villalta, , Juan I. Garaycoechea
The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.
Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology