Author

Foster C. Jacobs

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Silvia BalboiD· 3 shared Bérénice ChavaneliD· 2 shared Jiří ZavadiliD· 2 shared Ludmil B. AlexandroviD· 2 shared Michael KorenjakiD· 2 shared Shuvro Prokash NandiiD· 2 shared Yuhe ChengiD· 2 shared Adrian Baez‐OrtegaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenomics

Silvia BalboORCID

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Author profile →

3 papers

Recent·Most cited

Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK

Michael Korenjak, Nuri A. Temiz, Stéphane Keïta, Bérénice Chavanel, Claire Renard, Cécilia Sirand, Vincent Cahais, Tanguy Mayel, Karin R. Vevang, Foster C. Jacobs, Jiehong Guo, William E. Smith, Marissa K. Oram, Flaviu Tăbăran, Ozan Ahlat, , Jiří Zavadil

The paper identifies mutational signatures in cancer genomes caused by tobacco-specific nitrosamines NNN and NNK, showing their unique contribution to specific cancer types.

Genome Medicine · Jul 2, 2026Peer-reviewedGenomics

Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair

Yang Jiang, Moritz Jakob Przybilla, Linda V. Bakker, Foster C. Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E. E. Verkennis, Jamie T. Barnett, Adrian Baez‐Ortega, Federico Abascal, Peter W. Villalta, , Juan I. Garaycoechea

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic Mutations

Shuvro Prokash Nandi, Yuhe Cheng, Shams Al-Azzam, Safa Saeed, Audrey Kristin, Nadia Sunico, Isabella Stuewe, Zichen Jiang, Luka Culibrk, Maria Zhivagui, Xiaoxu Yang, Rachel M. Wise, Foster C. Jacobs, Bérénice Chavanel, Michael Korenjak, , Ludmil B. Alexandrov

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

bioRxiv · Sep 14, 2025 · PreprintGenomics