Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses.
E. A. Arnold, R. J. Kaai, K. Leung, M. R. Brinkley, L. E. Kelnhofer-Millevolte, M. S. Guo, D. C. Avgousti
This study shows adenovirus protein VII binds HMGB1's A-box to sequester it in chromatin, inhibiting interferon β expression but not downstream interferon-stimulated genes.
bioRxiv · Apr 17, 2023 · PreprintMicrobiology