K. Leung

Chloride Homeostasis Regulates cGAS-STING Signaling

This study shows chloride homeostasis regulates cGAS-STING signaling by affecting 23-cGAMP production, STING polymerization, and cytokine production in immune cells.

Linear Mixed Model of Virus Disinfection by Chlorine to Harmonize Data Collected Across Broad Environmental Conditions

The paper develops a linear mixed model to estimate chlorine inactivation rate constants for viruses under varying environmental conditions and identifies discrepancies in current disinfection guidelines.

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses.

This study shows adenovirus protein VII binds HMGB1's A-box to sequester it in chromatin, inhibiting interferon β expression but not downstream interferon-stimulated genes.

Imprinted anti-hemagglutinin and anti-neuraminidase antibody responses after childhood infections of A(H1N1) and A(H1N1)pdm09 influenza viruses

The paper characterizes anti-HA and anti-NA antibody responses to A(H1N1) and A(H1N1)pdm09 influenza viruses in individuals born between 1950-2015, finding age-dependent imprinting and cross-reactivity to multiple antigenic variants.

Higher habitual FODMAP intake is associated with lower body mass index, lower insulin resistance and higher short-chain fatty acid-producing microbiota in people with prediabetes

This study finds that higher habitual FODMAP intake in prediabetic individuals is linked to lower BMI, reduced insulin resistance, and increased SCFA-producing gut bacteria.

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster

This study measures age-related behavioral changes in Drosophila melanogaster and finds sexually dimorphic patterns linked to metabolic shifts.

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

Modulation of plant acetyl CoA synthetase activity by post-translational lysine acetylation

This study shows that acetylation of a specific lysine residue regulates plant acetyl-CoA synthetase activity, affecting acetate homeostasis.

High lumenal chloride in the lysosome is critical for lysosome function.

The paper measures lysosomal chloride levels in multiple models and finds that chloride reduction impairs lysosomal function.