S. Ramachandran

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation

This study shows that increased EZH2 activity in regulatory T cells enhances their effector differentiation and autoimmunity suppression capacity.

Chikungunya virus glycoproteins transform macrophages into productive viral dissemination vessels.

This study identifies CHIKV glycoproteins E2 and E1 as key factors that enable macrophages to support viral replication and dissemination by counteracting host restriction factors.

Extracellular vimentin is sufficient to promote cell attachment, spreading, and motility by a mechanism involving N-acetyl glucosamine-containing structures

This study shows extracellular vimentin promotes cell attachment, spreading, and motility via N-acetyl glucosamine-containing structures, identifying a novel adhesion mechanism.

Integrating sex-bias into studies of archaic admixture on chromosome X

This paper investigates how sex-bias in archaic hominin populations affects the retention of archaic DNA on chromosome X compared to autosomes using simulation studies.

HSV-1 exploits host heterochromatin for egress

This study shows HSV-1 uses host heterochromatin for viral egress, with loss of H3K27me3 or macroH2A1 causing capsid trapping.

Deceptive learning in histopathology

This paper analyzes whether deep learning models in histopathology learn trustworthy or deceptive strategies, finding that some recent advances in molecular profiling from H&E slides are unreliable.

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

Multiphoton microscopy for label-free multicolor imaging of peripheral nerve

This study uses multiphoton microscopy to label-free image peripheral nerve in mice and humans, comparing results to chemical stains and discussing clinical applications.

New Insights into the Mechanisms Used by Inhibitors Targeting Glutamine Metabolism in Cancer Cells

The paper investigates the mechanism of action of GAC inhibitors using crystallography and computational models, revealing conformational differences that affect potency.

Adaptive convergent evolution of genome proofreading in SARS-CoV2: insights into the Eigen's paradox

The paper traces the origin of proofreading in coronaviruses to the eukaryotic ZNFX1 gene and shows convergent evolution of genome stability mechanisms.

Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis.

This study identifies SLC38A5 as an upregulated amino acid transporter in triple-negative breast cancer that promotes macropinocytosis, expanding its role beyond amino acid transport to support cancer cell nutrition.

Hypoxia-induced SETX links replication stress with the unfolded protein response

This study shows hypoxia induces SETX, which protects cells from DNA damage by linking replication stress and the unfolded protein response.

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

This study determines the structure of SOCS2 bound to phosphorylated peptides, revealing substrate recognition mechanisms and implications for ligand design.

Localization of adaptive variants in human genomes using averaged one-dependence estimation

The paper introduces SWIF(r), a probabilistic method to detect selective sweeps and localize adaptive mutations in human genomes using population-genetic data.