α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance.
R. S. Jacob, A. Dema, H. Cherot, C. Dumesnil, S. Cohen, H. S. Shalom, N. Rimon, O. Sibony-Nevo, G. Beck, E. Ainbinder, H. Wolinski, K. Athenstaedt, F.-X. Theillet, A. R. THIAM, P. Selenko
This study shows α-Synuclein binds lipid droplets, senses cholesteryl-ester, regulates organelle size and abundance, and links its dysfunction to neurodegenerative diseases.
bioRxiv · Jun 19, 2024 · PreprintCell Biology