P. Selenko

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance.

This study shows α-Synuclein binds lipid droplets, senses cholesteryl-ester, regulates organelle size and abundance, and links its dysfunction to neurodegenerative diseases.

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.

This study shows that phosphatidylinositol polyphosphates mediate α-synuclein's plasma membrane localization in multiple cell types.

Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics.

This study examines megadalton-sized dityrosine aggregates of α-synuclein, revealing their structural disorder and dynamics, and their role in inhibiting classical amyloid formation.

An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo.

The paper develops an NMR-based biosensor to measure MSRA and MSRB activities in vitro and in vivo, showing differences in substrate specificity between prokaryotic and eukaryotic MSRs.

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

This study demonstrates that electroporation can deliver recombinant proteins into human cells, maintaining their localization, function, and interactions, making it a versatile tool for chemical and synthetic biology.

Quantitative mass imaging of single molecules in solution

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.