A. Dema

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.

Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

This study replaces endogenous EB1 with a light-sensitive variant in human neurons to show EB1's role in growth cone dynamics and neurite guidance through optogenetic inactivation.

Optogenetic EB1 inactivation shortens metaphase spindles by disrupting cortical force-producing interactions with astral microtubules

This study uses optogenetic inactivation of EB1 to show that it regulates metaphase spindle length by controlling astral microtubule interactions with cortical dynein/dynactin.

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.

This study shows that phosphatidylinositol polyphosphates mediate α-synuclein's plasma membrane localization in multiple cell types.