The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds
M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles
This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.
bioRxiv · Nov 2, 2020Biophysics