Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells
L. M. Sanmarco, J. M. Rone, C. M. Polonio, F. Giovannoni, G. Fernandez Lahore, K. Ferrara, C. Gutierrez-Vazquez, N. Li, A. Sokolovska, A. Plasencia, C. Faust Akl, P. Nanda, E. S. Heck, Z. Li, H.-G. Lee, , F. J. Quintana
The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.
bioRxiv · Mar 17, 2023 · PreprintImmunology