N. Li

Metabolic reshaping drives novel melanin production from tryptophan in a cystic fibrosis Pseudomonas aeruginosa clinical isolate

This study identifies a tryptophan-derived melanin in a Pseudomonas aeruginosa clinical isolate, showing iron deprivation promotes melanin production as a survival strategy in the cystic fibrosis lung.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Biomarker Identification by Proteomic Analysis of Vitreous Humor and Plasma in Diabetic Retinopathy

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.

Dynamic Visualization of DNA Methylation in Cell Cycle Genes during iPSC Cardiac Differentiation

The paper uses a genomic DNA methylation reporter system to track dynamic DNA methylation changes in cell cycle genes during iPSC cardiac differentiation, showing hypermethylation correlates with gene expression reduction.

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

This study shows bacterial ExoIII can cleave single-stranded DNA (ssDNA) via exonuclease and endonuclease activities, revealing new enzymatic functions and implications for biosensor design.

The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes

This study examines sex- and age-specific gene expression influenced by mitochondria in a species without sex chromosomes, finding sex-dimorphic energy metabolism and mito-nuclear interactions.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

WASP facilitates tumor mechanosensitivity in T lymphocytes

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

LrhA promotes CRISPR-Cas immunity by enhancing primed adaptation in Escherichia coli

This study identifies LrhA as a regulator that enhances CRISPR-Cas immunity in E. coli by promoting adaptation through increased spacer acquisition.

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

Mn2+-Induced Structural Flexibility Enhances the Entire Catalytic Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute Proteins

This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Soil intake modifies the gut microbiota and alleviates ovalbumin-induced mice asthma inflammation

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

Fibroblast-specific inflammasome activation predisposes to atrial fibrillation

This study shows that activating the NLRP3-inflammasome in cardiac fibroblasts leads to fibrosis, atrial cardiomyopathy, and atrial fibrillation.

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease

This study shows that combining IL-2 mutein with ImmTOR nanoparticles expands antigen-specific Tregs and protects against autoimmune diseases.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in mice

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores

This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells

The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.