Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2+ tumor immunity.
D. N. Sidiropoulos, C. Rafie, B. J. Christmas, E. F. Davis-Marcisak, G. Sharma, E. Bigelow, A. Gupta, S. Yegnasubramanian, V. Stearns, R. M. Connolly, D. A. Gaykalova, L. T. Kagohara, E. M. Jaffee, E. J. Fertig, E. T. Roussos-Torres
The paper uses single-cell RNA-sequencing to show entinostat shifts tumor microenvironment cell states, reducing immunosuppression and enhancing immune checkpoint inhibitor responses in HER2+ breast tumors.
bioRxiv · Jan 29, 2021 · PreprintImmunology