The pore-forming protein gasdermin D is a cellular redox sensor
P. Devant, E. Borsic, E. M. Ngwa, J. R. Thiagarajah, I. Hafner-Bratkovic, C. L. Evavold, J. C. Kagan
This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.
bioRxiv · Mar 11, 2022 · PreprintImmunology