Author

P. Devant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

J. C. Kagan· 3 shared A. Banerjee· 1 shared A. Cao· 1 shared A. Pitiriciu· 1 shared C. L. Evavold· 1 shared C. Schmidt· 1 shared C. Walker· 1 shared E. Borsic· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

J. C. Kagan

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Author profile →

4 papers

Recent·Most cited

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

G. Du, L. B. Healy, L. David, C. Walker, P. Fontana, Y. Dong, P. Devant, R. Puthenveetil, S. B. Ficarro, A. Banerjee, J. C. Kagan, J. Lieberman, H. Wu

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

bioRxiv · Mar 7, 2023Immunology

The pore-forming protein gasdermin D is a cellular redox sensor

P. Devant, E. Borsic, E. M. Ngwa, J. R. Thiagarajah, I. Hafner-Bratkovic, C. L. Evavold, J. C. Kagan

This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Evolution-inspired dissection of caspase activities enables the redesign of caspase-4 into an LPS sensing interleukin-1 converting enzyme

P. Devant, A. Cao, J. C. Kagan

The paper redesigns human caspase-4 to function as a single-protein LPS sensing pathway for IL-1β cleavage, inspired by carnivore caspases, and shows cat caspase-4 exhibits similar activity.

bioRxiv · Dec 7, 2020Immunology

Assembly defects of the human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

S. Sekulovski, P. Devant, S. Panizza, T. Gogakos, A. Pitiriciu, K. Heitmeier, E. P. Ramsay, M. Barth, C. Schmidt, S. Weitzer, T. Tuschl, F. Baas, J. Martinez, S. Trowitzsch

This study shows that TSEN assembly defects in PCH patients impair pre-tRNA processing by reducing cleavage activity despite normal endonuclease activity.

bioRxiv · Aug 3, 2020Biochemistry