Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in adenylate kinase 7 deficient ciliated epithelium.
J. Sheridan, A. Grata, E. E. Suva, E. Bresteau, L. R. Mitchell, B. Mitchell
This study shows that AK7 deficiency in Xenopus leads to ciliary defects, reduced centriole numbers, and impaired mucociliary flow, linking AK7 to primary ciliary dyskinesia.
bioRxiv · Jul 25, 2023Cell Biology