S. K. Kim

This study uses CRISPR/Cas9 RNP to edit regulatory DNA elements in human islet cells, revealing their role in diabetes risk and β cell function.

This paper determines the structure and dynamics of the mycobacterial polyketide synthase Pks13 using cryoEM and complementary techniques, revealing intermediate states and substrate binding.

The paper identifies two distinct mechanisms for multiciliated cell extrusion in Xenopus embryos: Notch-driven basal extrusion and Piezo1-driven apical extrusion, with age-dependent regulation.

The paper introduces a 30-minute multiplexed immunoassay for identifying and quantifying pneumococcal vaccine antigens with high specificity and precision.

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

This paper develops a mouse model for studying islet transplantation tolerance by creating a congenic line that allows controlled diabetes induction and assessment of islet engraftment.

This study shows that tubulin acetylation enhances the penetrative capacity of cells during radial intercalation in Xenopus embryos by influencing their ability to insert into epithelial barriers.

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

This study identifies distinct autoinhibitory mechanisms in T-catenin and E-catenin regulating vinculin binding, showing that T-catenin's N-terminus maintains M-region autoinhibition.

The paper identifies ciliary GPCRs in pancreatic islet cells that regulate insulin and glucagon secretion, with FFAR4 and PTGER4 as key targets for diabetes therapy.

This study uses CRISPR/Cas9 to create mice lacking human glucagon to study human islet glucagon secretion in vivo after transplantation.