The orphan ligand, Activin C, signals through activin receptor-like kinase 7
E. J. Goebel, L. Ongaro, E. C. Kappes, E. Belcheva, R. Castonguay, R. Kumar, D. J. Bernard, T. Thompson
This study characterizes the signaling properties of Activin C and its heterodimer ActAC, showing they activate SMAD2/3 via ALK7 with distinct receptor and antagonist profiles compared to ActA and ActB.
bioRxiv · Mar 16, 2022Biochemistry