R. Kumar

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

Structural Characterization of DNA Binding Domain of Essential Mammalian Protein TTF 1

This study characterizes the DNA-binding Myb domain of TTF1 using computational modeling and experimental validation, confirming its predominantly helical structure.

Synovial fluid transcriptome dynamics in osteoarthritis progression: Implications in pathogenesis

This study identifies gene expression changes and pathways involved in osteoarthritis progression using synovial fluid transcriptomes from different OA grades.

The C-terminal regulatory domain of IPMS enzyme maintains leucine homeostasis by bypassing a hidden negative feedback loop in plants

This study shows that removing the C-terminal regulatory domain of IPMS in plants disrupts leucine homeostasis by enabling pathway intermediates to inhibit IPMS activity.

Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs

This study enhances the affinity of SARS-CoV-2 neutralizing nanobodies through structure-guided mutations in CDRs, resulting in improved neutralization activity against pseudovirus.

Wheat Enhanced Disease Resistance EMS-Mutants Include Lesion-mimics With Adult Plant Resistance to Stripe Rust

The paper identifies 16 wheat mutants with enhanced resistance to stripe rust and other fungal pathogens through forward genetic screening and maps their mutations to a long-read genome.

FIGL1 attenuates meiotic interhomolog repair and is counteracted by RAD51 paralog XRCC2 and chromosome axis protein ASY1 during meiosis

This study identifies FIGL1's role in attenuating meiotic interhomolog repair and shows that XRCC2 and ASY1 counteract FIGL1's effects in Arabidopsis.

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

High-frequency amplitude-modulated sinusoidal stimulation desynchronizes neural activity and enhances naturalness of evoked sensations

This paper introduces a new electrical stimulation waveform that evokes more naturalistic neural activity than traditional methods, as shown by human experiments and computational modeling.

Spatial top-down proteomics for the functional characterization of human kidney

This paper develops a spatial proteomics workflow to identify and map proteoforms in human kidney tissue, revealing spatially distinct proteomic profiles between glomeruli and tubules.

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.

This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

Rumen protozoa are a hub for diverse hydrogenotrophic functions

The paper investigates the role of rumen ciliate protozoa in hosting prokaryotic communities involved in hydrogenotrophic functions, showing stable associations despite changes in the microbial community.

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.

Machine Learning Elucidates Design Features of Plasmid DNA Lipid Nanoparticles for Cell Type-Preferential Transfection

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.

Lack of Purple Acid Phosphatase SlPAP26b compromises the phosphorous starvation response in tomato independent of SlPHR1 and SlPHL1

This study identifies SlPAP26b as a key player in tomato's phosphorus starvation response, independent of SlPHR1 and SlPHL1, through transcriptomics and proteomics analysis.

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

This study shows that inhibiting the integrated stress response (ISR) or PKR reduces vascular remodeling in PVOD models, suggesting potential therapeutic strategies.

Holistic in silico developability assessment of novel classes of small proteins using publicly available sequence-based predictors

This paper develops machine learning models to predict the developability of Anticalin proteins using sequence-based descriptors, achieving low prediction errors and validated through cross-validation.

Support Vector Machine based prediction models for drug repurposing and designing novel drugs for colorectal cancer

This study develops QSAR models and a webserver to predict novel drugs and repurpose existing ones for colorectal cancer treatment using pharmacological profiles and in-silico validation.

Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants

This study uses deep learning to identify antibodies resistant to SARS-CoV-2 Omicron variants by predicting their binding and escape from mutations.

p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein

This study shows that p38-MAPK is essential for SARS-CoV-2 replication, as its inhibition reduces viral growth and its activation supports RNA/protein synthesis without affecting viral entry or budding.

DENND6A couples Arl8b to a Rab34/RILP/dynein complex regulating retrograde lysosomal trafficking and autophagy

This study identifies DENND6A as a Rab34 GEF that couples with Arl8b to regulate lysosomal retrograde trafficking and autophagy.

A geminivirus AC5 protein interacts with plant hormonal signalling and impacts plant defence

This study identifies AC5, a geminiviral protein, as interacting with the abscisic acid signaling pathway, impairing plant defense and facilitating virus propagation.

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

This paper identifies the alphavirus TF protein's role in promoting viral propagation by altering cell-cell boundaries through downregulation of Scribble.

Restriction of the growth and biofilm formation of ESKAPE pathogens by caprine gut-derived probiotic bacteria

This study isolates and evaluates caprine gut-derived lactic acid bacteria for their antimicrobial and antibiofilm activities against ESKAPE pathogens, highlighting their potential as probiotics and alternatives to antibiotics.

Macromolecular Crowding Promotes Reentrant Liquid-Liquid Phase Separation of Human Serum Transferrin and Prevents Surface-Induced Fibrillation

This study shows that macromolecular crowding promotes liquid-liquid phase separation of human serum transferrin, preventing surface-induced fibrillation and preserving its native-like conformation.

A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2

This paper develops a recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 that elicits broad neutralization against variants and provides protection in animal models.

Divergent proinflammatory immune responses associated with the differential susceptibility of cattle breeds to Tuberculosis

This study investigates immune responses in Indian cattle breeds to identify why crossbred cattle are more susceptible to tuberculosis than indigenous breeds.

Identification of Iron Deficiency-Induced Chlorosis Tolerant Lines from Wild Rice Germplasm

The paper identifies 20 wild rice lines tolerant to iron deficiency-induced chlorosis under aerobic conditions and confirms their consistent tolerance over two years.