Author

L. Ongaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. J. Bernard· 4 shared G. Schang· 2 shared R. Castonguay· 2 shared X. Zhou· 2 shared A. Aldridge· 1 shared A. Bartlett· 1 shared A. Deaton· 1 shared A. Dubey· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

D. J. Bernard

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Author profile →

4 papers

Recent·Most cited

Activin E is a TGFβ ligand that signals specifically through activin receptor-like kinase 7.

K. A. Vestal, C. Kattamuri, M. Koyiloth, L. Ongaro, J. A. Howard, A. Deaton, S. Ticau, A. Dubey, D. J. Bernard, T. B. Thompson

This study identifies Activin E as a TGFβ ligand that signals through ALK7, using canonical activin receptors and SMAD2/3 pathways, similar to Activin C.

Biochemical Journal · Apr 10, 2024Peer-reviewedBiochemistry

Myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

L. Ongaro, X. Zhou, Y. Wang, Z. Zhou, H. Schultz, E. R. S. Buddle, E. Brule, Y.-F. Lin, G. Schang, R. Castonguay, Y. Liu, G. H. Su, N. Seidah, K. C. Ray, S. J. Karp, , D. J. Bernard

The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.

bioRxiv · Aug 30, 2023 · PreprintPhysiology

The orphan ligand, Activin C, signals through activin receptor-like kinase 7

E. J. Goebel, L. Ongaro, E. C. Kappes, E. Belcheva, R. Castonguay, R. Kumar, D. J. Bernard, T. Thompson

This study characterizes the signaling properties of Activin C and its heterodimer ActAC, showing they activate SMAD2/3 via ALK7 with distinct receptor and antagonist profiles compared to ActA and ActB.

bioRxiv · Mar 16, 2022Biochemistry

Single nucleus multi-omics regulatory atlas of the murine pituitary

F. M. Ruf-Zamojski, Z. Zhang, M. Zamojski, G. R. Smith, N. Mendelev, H. Liu, G. Nudelman, M. Moriwaki, H. Pincas, R. Gomez Castanon, V. D. Nair, N. Seenarine, M. A. S. Amper, X. Zhou, L. Ongaro, , S. C. Sealfon

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.

bioRxiv · Jun 6, 2020 · PreprintCell Biology