Author

E. Cacace

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Typas· 3 shared A. Mateus· 2 shared A. Milanese· 2 shared G. Zeller· 2 shared M. Knopp· 2 shared M. Tietgen· 2 shared P. Bork· 2 shared A. Brauer· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

A. Typas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

E. Cacace, M. Tietgen, M. Steinhauer, A. Mateus, T. G. Schultze, M. Eckermann, M. Galardini, V. Varik, A. Koumoutsi, J. J. Parzeller, F. Corona, A. N. Orakov, M. Knopp, A. Brauer-Nikonow, P. Bork, , S. Goettig

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

bioRxiv · Jun 4, 2024Microbiology

High-throughput profiling of drug interactions in Gram-positive bacteria

E. Cacace, V. Kim, M. Knopp, M. Tietgen, A. Brauer, K. Inecik, A. Mateus, A. Milanese, M. Torrissen Marli, K. Mitosch, J. Selkrig, A. R. Brochado, O. Kuipers, M. Kjos, G. Zeller, , A. Typas

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

bioRxiv · Dec 23, 2022 · PreprintMicrobiology

Dissecting the collateral damage of antibiotics on gut microbes

L. Maier, C. V. Goemans, M. Pruteanu, J. Wirbel, M. Kuhn, E. Cacace, T. Banerjee, E. E. Anderson, A. Milanese, U. Loeber, S. K. Forslund, K. R. Patil, G. Zeller, P. Bork, A. Typas

This study characterizes the antibiotic activity spectrum on gut bacteria, revealing species-specific effects and identifying antidotes to mitigate collateral damage.

bioRxiv · Jan 9, 2020Microbiology