A. Mateus

Essentiality of LD-Transpeptidation in Agrobacterium tumefaciens

This study identifies the essential role of LD-transpeptidation in Agrobacterium tumefaciens cell wall integrity and growth by analyzing LDTs and their genetic interactions.

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

Mechanical loading modulates AMPK and mTOR signaling in myblasts

This study investigates how mechanical loading affects AMPK and mTOR signaling in myoblasts, showing that 10% static loading activates AMPK and inhibits mTOR, alters RNA/protein synthesis, and impacts mitochondrial biogenesis.

A shade-responsive microprotein in ATHB2 regulates Arabidopsis growth and root development

The paper identifies a microprotein from ATHB2 that regulates Arabidopsis growth and root development by modulating DNA-binding activity and light responses.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

High-throughput profiling of drug interactions in Gram-positive bacteria

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae

This study identifies a novel arsenate resistance mechanism in V. cholerae involving the formation of a transient glycolytic complex to sequester arsenate and prevent its toxic effects.

Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers

The paper uses thermal proteome profiling to detect proteoforms and drug sensitivity biomarkers in acute lymphoblastic leukemia cell lines.

Phage proteins block and trigger retron toxin/antitoxin systems

The paper identifies phage proteins that block or trigger retron toxin/antitoxin systems in bacteria, revealing their role in anti-phage defense.

Bacterial retrons encode tripartite toxin/antitoxin systems

The paper identifies retrons as a novel family of tripartite toxin/antitoxin systems in bacteria, with the reverse transcriptase and msDNA functioning as antitoxin components.

A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli

This study identifies NlpI as a scaffold for PG hydrolases in E. coli, forming multi-enzyme complexes that coordinate PG synthesis and hydrolase activity.