CRISPR editing of sftb-1/SF3B1 in C. elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing
X. Serrat, D. Kukhtar, E. Cornes, A. Esteve-Codina, H. Benlloch, G. Cecere, J. Ceron
The paper uses CRISPR to edit sftb-1/SF3B1 in C. elegans to identify synthetic interactions with cancer mutations and test splicing inhibitors.
bioRxiv · Jun 11, 2019 · PreprintCancer Biology